DO - use something which will be waterproof when dry and allow plenty of time to dry and air out.
Also seal the joins, especially around the floor. You want to do this because a big wet mess or spilled water may drip down and make a mess of everything below. Ask at your local hardware store for recommendation. If it has been sealed well, clear silicone should be good. I have white melamine enclosures, so use white gap filler or bathroom sealant.